Difference between plasma and serum

A usual misunderstanding among people is that plasma and serum is the similar things. They are two distinctive substances with the same precursor solution and containing constituents, which makes them unusual and necessary for various medical remedies.[wp_ad_camp_1]

The usual ancestor is blood, and the standard of purification of the blood is the effect of plasma and serum. When we discuss the ingredient from which blood is made from, it is made up of red blood cells, white blood cells, platelets, proteins, and a liquid substance. The above discussed two substances are essential in therapeutic and diagnostic procedures in humans, and currently different research is being conducted regarding the unique nature of these substances.[wp_ad_camp_1]


Plasma is the essential watery portion of the blood. We are able to observe and understand plasma, if we stand a column of blood for about one hour of time, we can observe the precipitation of red cells and white cells with a supernatant straw coloured liquid. This liquid is known as plasma. Plasma has fibrinogen, an essential factor in the clotting process and other main factors of clotting. Thus, on standing this straw coloured liquid tends to clump. This plasma can be easily spun, so the protein materials with heavy mass tend to precipitate down, leaving better purified plasma. Plasma is very important for diagnostic investigation and is very necessary for therapeutic transfusions in people, who are hypovolemic, deficient in clotting factors, etc. A lesser clot prone plasma is available as cryo poor plasma (CPP), and the eliminated clotting agents are used in the treatment of haemophiliacs as cryo precipitate.


Serum is considered to be plasma without any kind of clotting, mainly the fibrinogen. So we know that serum alone does not tend to clot. Usually, to extract serum, all clotting agents in plasma are eliminated via progressive centrifuging, or we can obtain a blood sample and after allowing it to clot, the supernatant is taken. Serum has all the other electrolytes, proteins not used in the clotting process, drugs and toxins. Human serum is basically used for the purpose of diagnostic testing. The serum of animals is used as anti-venom, anti toxins, and vaccinations.

Difference between Plasma and Serum

Plasma and serum both of them are the derivatives of blood. Both of them have electrolytes, other proteins, drugs, hormones and toxins. Both can be obtained from centrifugation and purity depending up on the duration and the frequency of this process.[wp_ad_camp_1]

Both of them are used and are essential for diagnostic and therapeutic purposes. Plasma is serum with fibrinogen and various clotting factors. So plasma tends to discolour on standing, while on the other hand serum does not. Extraction and separation of plasma is competitively easy and inexpensive, while on the other hand separation of serum needs higher levels of expertise and expenses. Plasma is most usually used for therapeutic purposes while on the other hand Serum is very usually used for diagnostic purposes. The sera of animals are used and are important in humans for therapeutic purposes.


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